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Heart rate changes by dose group At the 12 mg dose (the highest tested), the average heart rate increase peaked at approximately 6.7 beats per minute at week 24

The idea is to provide just enough UV stimulus to activate the MT-1-primed melanocytes without causing burning or significant DNA damage

Consequently, regarding the formation of multidrug resistance in tumor cells, besides acting as a detoxification enzyme though excretion of drugs to decrease pharmacological efficacy, GST can also act as an MAPK-pathway inhibitor to improve tumor-cell survival

To ensure the best results and minimize potential side effects, the dosage is gradually increased over time

Azuaga AB, Ramrez J, Caete JD